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  • PACS: 13.60.Le Meson production – 25.40.Ep Inelastic proton scattering  (1)
  • cell death  (1)
  • in situ hybridization  (1)
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  • 1
    ISSN: 1435-1463
    Keywords: GDNF ; in situ hybridization ; cell death ; Parkinson's disease ; adult ; newborn infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for dopaminergic neurons. Since dopaminergic neurons degenerate in Parkinson's disease, this factor is a potential therapeutical tool that may save dopaminergic neurons during the pathological process. Moreover, a reduced GDNF expression may be involved in the pathophysiology of the disease. In this study, we tested whether altered GDNF production may participate in the mechanism of cell death in this disease. GDNF gene expression was analyzed by in situ hybridization using riboprobes corresponding to a sequence of the exon 2 human GDNF gene. Experiments were performed on tissue sections of the mesencephalon and the striatum from 8 patients with Parkinson's disease and 6 control subjects matched for age at death and for post mortem delay. No labelling was observed in either group of patients. This absence of detectable expression could not be attributed to methodological problems as a positive staining was observed using the same probes for sections of astroglioma biopsies from human adults and for sections of a newborn infant brain obtained at post-mortem. These data suggest that GDNF is probably expressed at a very low level in the adult human brain and its involvement in the pathophysiology of Parkinson's disease remains to be demonstrated. GDNF may represent a powerful new therapeutic agent for Parkinson's disease, however.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 4 (1999), S. 259-275 
    ISSN: 1434-601X
    Keywords: PACS: 13.60.Le Meson production – 25.40.Ep Inelastic proton scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We evaluate the threshold matrix–element for the reaction pp→ppπ0 in a fully relativistic Feynman diagrammatic approach. We employ a simple effective range approximation to take care of the S–wave pp final–state interaction. The experimental value for the threshold amplitude A = (2.7 −i0.3) fm4 can be reproduced by contributions from tree level chiral (long–range) pion exchange and short–range effects related to vector meson exchanges, with ω-exchange giving the largest individual contribution. Pion loop effects appear to be small. We stress that the commonly used heavy baryon formalism is not applicable in the NN–system above the pion production threshold due to the large external momentum, |p|≃ (Mm π)−1/2, with M and m π the nucleon and the pion mass, respectively. We furthermore investigate the reaction pp→pnπ+ near threshold within the same approach. We extract from the data the triplet threshold amplitude as B = (2.8 −i1.5) fm4. Its real part can be well understood from (relativistic) tree level meson–exchange diagrams. In addition, we investigate the process pp→ppη near threshold. We use a simple factorization ansatz for the ppη final–state interaction and extract from the data the modulus of the threshold amplitude, |C|= 1.32 fm4. With g ηN= 5.3, this value can be reproduced by (relativistic) tree level meson–exchange diagrams and η–rescattering, whose strength is fixed by the ηN scattering length. We also comment on the recent near threshold data for η′–production.
    Type of Medium: Electronic Resource
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