ISSN:
1569-8041
Keywords:
first-line therapy
;
fludarabine and mitoxantrone
;
LG-NHL
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Purpose:In the last years, fludarabine (FLU) alone or incombination with other drugs has been reported to be effective in thetreatment of previously treated low-grade non-Hodgkin's lymphomas (LG-NHL).The aim of this study was to define the therapeutic efficacy and toxicity ofa combination of FLU and mitoxantrone (FN regimen) in untreated LG-NHL. Patients and methods:We used a two-drug combination of FLU (25mg/m2 i.v. on days 1 to 3) and mitoxantrone (10 mg/m2i.v. on day 1) to treat 27 previously untreated patients with LG-NHL.Chemotherapy was repeated every four weeks for a total of six cycles. Among27 patients, 17 (63%) were diagnosed with follicular, 6 (22%)with small lymphocytic, and 4 (15%) with immunocytoma subtypes. Results:Of the 27 patients, 18 (67%) achieved completeresponse (CR) and 6 (22%) partial response, while the remaining 3(11%) showed no benefit from the treatment. Regarding histology, in thefollicular subtype we observed an overall response rate of 94%, witha 76.5% CR rate. The estimated two-year relapse-free survival was83%, and overall survival was 92%. Hematologic grade 3–4toxicity was seen in only five (3.3%) patients; no opportunisticinfections or deaths were associated with the administration of the FNregimen. Conclusions:These preliminary data show that the FN regimen isa very active, well-tolerated combination chemotherapy for untreated patientswith advanced LG-NHL.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008388824069
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