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  • Paediatric intensive care  (1)
  • absorption  (1)
  • drug interaction  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Extent and pharmacokinetic mechanisms of oral atenolol-verapamil interaction in man (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 363-366 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; atenolol ; drug interaction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Chronic coadministration of oral verapamil with oral atenolol resulted in a variable increase in atenolol steady-state plasma concentrations in a group of 10 patients on chronic maintenance therapy. Individual subjects showed changes in area under the plasma atenolol concentration-time curve (AUC) of more than 100%, however group comparisons did not achieve statistical significance unless normalized for verapamil dose. Renal clearance of atenolol was shown to be decreased by more than 25% in 2 subjects studied using intravenous dosing of atenolol. This interaction is likely to contribute to the documented clinical intolerance of combinations of atenolol and verapamil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561365
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Absorption and elimination of bismuth from oral doses of tripotassium dicitrato bismuthate (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 533-536 
    Details
    ISSN: 1432-1041
    Keywords: bismuth ; absorption ; elimination ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of bismuth subcitrate were studied in plasma and urine under conditions of single and multiple dosing (28–56 days) using atomic absorption technique. Single dose plasma pharmacokinetics showed peak concentrations of 5.5–57.5 µg·l−1 (mean=24.7 µg·l−1), reached between 30 and 60 min post dosing with an apparent biphasic elimination pattern. Multiple dose studies showed a continuing rise in plasma concentration and urine excretion rate reaching apparent steady-state levels over 7–29 days (mean=18 days). Washout studies in 6 individuals reciprocated accumulation. Maximum equilibrated plasma levels of 7.6–58.3 µg·l−1 (mean=38.3 µg·l−1) were well below those associated with encephalopathy. The half-life of bismuth elimination was 20.7 days. Present patterns of intermittent dosing with bismuth are unlikely to be associated with bismuth accumulation despite slow accumulation and elimination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558139
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Extradural haemorrhage in infancy and childhood (1990)
    Springer
    Child's nervous system 6 (1990), S. 383-387 
    Details
    ISSN: 1433-0350
    Keywords: Extradural haematoma ; Paediatric intensive care ; Computed tomography ; Emergency medical services ; Aeromedical transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred and two paediatric cases of extradural haemorrhage (EDH) were treated in Adelaide, South Australia, during the period 1954–1988; 10 were infants (0–2 years) and 92 were children (2–14 years). There were 9 deaths (mortality 8.8%). Long-term disabilities severe enough to interfere with school and/or employment were seen in 8 (7.8%) survivors. This relatively low number of adverse outcomes is partly an expression of a low incidence (5.9%) of associated intradural haematomas and few high-velocity impacts due to vehicular accidents. There is reason to believe that the results of treatment have improved in the decade 1977–1988. We attribute this in part to early diagnosis by computed tomography (CT), but a contributory factor may be earlier referrals from country centres to a paediatric trauma centre and rapid transfer, by air or road, by medical retrieval teams.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302223
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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