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  • 1
    Electronic Resource
    Electronic Resource
    Pantoprazole does not affect cyclosporin A blood concentration in kidney-transplant patients (2000)
    Springer
    European journal of clinical pharmacology 55 (2000), S. 733-735 
    Details
    ISSN: 1432-1041
    Keywords: Key words Proton-pump inhibitors ; Pantoprazole ; Cyclosporin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Renal-transplant patients who are immunosuppressed with cyclosporin A (CyA) are often treated with proton-pump inhibitors to prevent ulcer disease. No data are available on the effect of the novel proton-pump inhibitor pantoprazole on CyA levels. Methods: In a controlled treatment, we investigated the effect of pantoprazole, which was administered in a pragmatic schedule for acid suppression (40 mg as single oral dose at 2200 hours) in six renal-transplant patients who received CyA (Sandimmun optoral, 50–175 mg twice daily) and prednisolone (5–7.5 mg/24 h). CyA trough levels (0730–0800 hours) were measured by immunoassay. Results: In the absence of pantoprazole, mean CyA trough levels measured on three consecutive days were between 164 ng/ml and 173 ng/ml (therapeutic range 120–200 ng/ml). Pantoprazole did not affect CyA trough levels during an observation period up to 3 months long. Conclusions: Pantoprazole seems to be a safe drug in combination with CyA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050006
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  • 2
    Electronic Resource
    Electronic Resource
    Chirurgische Therapie benigner Lebertumoren (1997)
    Springer
    Der Internist 38 (1997), S. 944-953 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Lebertumoren ; Therapie ; Lebertumoren ; benigne ; Hämangiom ; Leber ; Fokal noduläre Hyperplasie ; Leber ; Leberadenom ; Präkanzerose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Durch Sonographie, Farb-Doppler-Technik, Computer- und Magnetresonanztomographie sowie szintigraphische Methoden gelingt in aller Regel eine gute Differenzierung der häufigsten benignen Lebertumoren. Ergänzt wird diese natürlich durch klinische und humorale Untersuchung unter Einschluß von Tumormarkern, um die Verdachtsdiagnose maligne oder benigne zu untermauern. Die Biopsie sollte weitgehend vermieden werden, da die meistens sichere Diagnostik eindeutig nichtmaligner Strukturen durch die genannten Verfahren möglich ist und malignitätsverdächtige Strukturen ohnehin eine Operation notwendig machen, sofern der Zustand des Patienten dies erlaubt. In dieser Arbeit werden nur die benignen soliden Lebertumoren behandelt, nicht die (poly-)zystischen, parasitär zystischen Lebererkrankungen und Abszesse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050105
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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