ISSN:
1435-1463
Keywords:
Parkinson's disease
;
serotonin receptors
;
receptor binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Crude membrane preparations from the frontal cortex of controls and parkinsonian patients were used to demonstrate affinity changes of the specific3H-5-hydroxytryptamine (5-HT) binding sites. Two such sites were noteable in controls, a finding consistent with earlier observations. In Parkinson's disease, both high- and low-affinity sites are significantly decreased. Additional experiments either with prolonged incubation times or pre-incubation with N-ethylmaleimide change the two affinities to a single high-affinity or low-affinity constant. The concept of transitional states of 5-HT receptors is discussed and seems to have important implications in the treatment of parkinsonism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01664009
Permalink
