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Digitale Medien

On the optimal dosage of Pro-Leu-Gly-NH2 (MIF) in neuropharmacological tests and clinical use (1977)

Björkman, Sven ; Sievertsson, Hans

Springer

Naunyn-Schmiedeberg's archives of pharmacology 298 (1977), S. 79-81

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Details

ISSN: 1432-1912

Schlagwort(e): MIF ; Melanostatin ; Oxotremorine ; Parkinson ; Peptides

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Pro-Leu-Gly-NH2 (MIF) inhibits the tremor induced by oxotremorine. Objective measurement of this tremor permits the drawing of a dose-effect curve. The inhibitory effect of the peptide increases linearly with increasing doses until an optimum is reached (between 30 and 40 mg/kg i.p.). At still higher doses the peptide is inactive. The same phenomenon is observed with analogues of MIF. This finding may have important bearings on the interpretation of clinical and experimental data obtained with MIF.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00508614

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