ISSN:
1573-2592
Keywords:
Pathological hyperprolactinemia
;
T lymphocytes
;
prolactin
;
neuroendocrine system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The phenotype and function of T cells circulating in patients with pathological hyperprolactinemia were analyzed and compared to those in sex- and age-matched control subjects. Two-color immunofluorescence study revealed an increased number of CD4+ TQ1+ cells and the presence of phenotypically immature CD1+ T cells, also exhibiting transferrin surface receptor, in peripheral blood of the hyperprolactinemic patients. After chronic treatment with the dopamine agonist bromocriptine, T-cell abnormalities disappeared. In addition, some untreated patients showed enhanced T-cell suppressor activity in anin vitro pokeweed mitogen-driven B-cell transformation assay. These immunological findings confirm a link between neuroendocrine and immune systems in humans.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00915056
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