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  • Peak compression  (1)
  • Pharmacokinetic  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Interaction study between remoxipride and biperiden (1993)
    Springer
    Psychopharmacology 111 (1993), S. 27-32 
    Details
    ISSN: 1432-2072
    Keywords: Pharmacokinetic ; Pharmacodynamic ; Interaction ; Remoxipride ; Biperiden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse events were recorded to assess pharmacodynamic interactions. Remoxipride and biperiden had no effect on each other's plasma concentrations. Biperiden did not affect the urinary recovery or renal clearance of remoxipride. Prolactin levels were unaffected by biperiden but increased following remoxipride administration. Differences in prolactin Cmax and tmax following remoxipride versus concomitant (remoxipride + biperiden) treatment were not statistically significant. However, a slight but statistically significant (P=0.04) increase in prolactin AUC was observed after concomitant treatment. No significant differences could be observed between the recorded salivary flow in all the treatment sessions. Single doses of remoxipride and biperiden showed no pharmacokinetic or pharmacodynamic interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257403
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reversed phase liquid chromatographic assay of FLA 908, a metabolite of remoxipride, in hydrolysed urine by means of a peak compression effect (1986)
    Springer
    Chromatographia 22 (1986), S. 283-286 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ion-pair chromatography ; Peak compression ; Remoxipride metabolite ; Conjugate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary FLA 908 was identified as a metabolite of remoxipride in human urine after enzymatic hydrolysis. The identity was proven by comparison of its retention time in LC and its UV and mass spectra to authentic FLA 908. The concentration of FLA 908 in human urine was determined using chromatographic conditions where a peak compression effect was obtained. This effect, giving an extremely narrow peak for FLA 908, made it possible to determine low concentrations of the compound in enzymatically hydrolyzed urine. The limit of quantitation was improved more than by a factor of 5 compared to conventional chromatography and the precision was good with a coefficient of variation of 〈5%. Less than 1% (0.44–0.91%) of the administered remoxipride dose was found to be excreted as conjugated FLA 908 while only trace amounts (≤0.01%) of nonconjugated FLA 908 were seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268775
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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