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Solid-Phase Synthesis of Oligourea Peptidomimetics (1999)

Boeĳen, Astrid ; Liskamp, Rob M. J.

Weinheim : Wiley-Blackwell

Liebigs Annalen 1999 (1999), S. 2127-2135

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ISSN: 1434-193X

Keywords: Oligourea peptidomimetics ; Photocleavable linker ; Solid-phase synthesis ; Isocyanates ; Hydantoins ; Chemistry ; General Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A procedure for the solid-phase synthesis of oligourea peptidomimetics starting from Boc-protected monomers is described. The compounds are prepared on Tentagel® resin and can be obtained selectively either as the C-terminal free acids with UV irradiation when a photocleavable linker is used or as C-terminal hydantoins with 10% TEA/MeOH and a catalytic amount of KCN.

Additional Material: 3 Ill.

Type of Medium: Electronic Resource

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