ISSN:
1432-0533
Keywords:
Histamine
;
Cerebral ventricle
;
Pinocytosis
;
Brain-blood barrier
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Histamine dihydrochloride (10 μg of 500 μg/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, ranitidine, injected with histamine was able to inhibit the stimulation of pinocytosis. Albumin exudation from the blood was not found. There was also no change in water and electrolyte contents of the brain tissue. The results suggest that histamine reaching the abluminal membrane can activate the pinocytosis in the cerebral endothelial cells in the reverse direction, i.e., from brain to blood, without opening the blood-brain barrier.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00686387
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