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  • 1
    Electronic Resource
    Electronic Resource
    Diagnostik und Therapie der hämorrhagischen Diathese in der perioperativen Situation (1999)
    Springer
    Gefässchirurgie 4 (1999), S. 5-12 
    Details
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Blutungsneigung ; Hämorrhagische Diathese ; Erworbene und angeborene Thrombopathien ; Plasmatische Gerinnungstörungen ; DDAVP ; Key words Bleeding tendency ; Hemorrhagic diathesis ; Acquired and congenital qualitative platelet disorders ; Blood coagulation disorders ; Deamino-d-arginine vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In surgical procedures associated with high blood loss, such as vascular and cardiac operations, differential diagnosis and therapy of perioperative hemorrhage are of special importance. Preoperative screening for patients at high risk of bleeding and in particular for those with qualitative platelet disorders [drug-induced platelet disorders (in particular ASS), von Willebrand's disease and other congenital platelet disorders] is effective in minimizing blood loss. Bleeding in acute medical emergencies or during emergency operations may require treatment without specific investigations being performed in advance. Therefore, simple schemes are essential for the rapid management of acute hemostatic problems. The aim of this paper was to address the diagnostic and therapy of hemorrhagic diathesis focusing mainly on diagnosis and therapy of hemorrhagic diathesis due to blood platelet disorders and blood coagulation disorders and preoperative identification of patients at increased risk of bleeding.
    Notes: Zusammenfassung Die Differentialdiagnostik und Therapie von perioperativen Blutungen besitzt in der Gefäß- und Kardiochirurgie bei Eingriffen mit hohen Blutverlusten einen besonderen Stellenwert. So ist es sinnvoll, Patienten mit einem erhöhten Blutungsrisiko bereits präoperativ zu erfassen und adäquat vorzubereiten. Insbesondere die präoperative Erfassung von Thrombopathien [medikamenteninduzierte Thrombopathien (insbesondere durch ASS), von-Willebrand-Jürgens-Syndrom, andere angeborene Thrombopathien] ist bei der Minimierung von Blutverlusten effektiv. Nicht elektive Situationen (Blutung bei Notoperationen, Akutpatienten) müssen oft ohne gezielte hämostaseologische Diagnostik rational therapiert werden. Einfache Schemata sind für ein schnelles Handeln unabdingbar. In dieser Arbeit soll versucht werden, Hinweise zu Diagnostik und Therapie der hämorrhagischen Diathese mit den Schwerpunkten: Diagnostik und Therapie der thrombozytär bedingten hämorrhagischen Diathese und Diagnostik und Therapie der plasmatisch bedingten hämorrhagischen Diathese aus hämostaseologisch-transfusionsmedizinischer Sicht zu vermitteln. Ein für den Routinebetrieb auf chirurgischen Stationen anwendbares Schema zur präoperativen Erfassung von Patienten mit erhöhtem Blutungsrisiko sowie erste Erfahrungen damit werden vorgestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010539
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation of a pure autologous biodegradable fibrin matrix for tissue engineering (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 686-689 
    Details
    ISSN: 1741-0444
    Keywords: Tissue engineering ; Autologous fibrinogen ; Thrombin ; Matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Parallel to the growing role of tissue engineering, the need for cell embedding materials, which allow cells to stabilise in a three-dimensional distribution, has increased. Although several substances have been tested, fibrin is thus far the only one that permits the clinical application of cultured tissue. To date, can cause severe immunological side effects. The objective of this study was to explore the practicability of obtaining autologous thrombin from a single patient in an adequate concentration and amount. Fibrinogen was cryoprecipitated from 200 ml of freshly-frozen plasma. Thrombin was isolated from the supernatant through ionexchange chromatography. The thrombin was first bound to Sephadex A-50 and then eluated using 2ml of a salt buffer (2.0M NaCl in 0.015M trisodiumcitrate, pH 7.0). The activity of the thrombin (51 NIH ml−1 to 414 NIH ml−1) reached levels comparable to those in commercially available fibrin glues (4–500 NIH ml−1). The study has shown that it is possible to obtain a sufficient amount of autologous thrombin from a single donor to create a fibrin matrix of high efficiency without the risk of immunological and infectious side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02344876
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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