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  • Polymer and Materials Science  (3)
  • autoantibodies  (1)
  • autoantigens  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Human Anti-Ro Autoantibodies Bind Multiple Conformational Epitopes of 60-kD Ro Autoantigen (1997)
    Springer
    Journal of clinical immunology 17 (1997), S. 212-219 
    Details
    ISSN: 1573-2592
    Keywords: Systemic lupus erythematosus ; autoantibodies ; autoantigens ; antinuclear antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A gel filtration method was developed to estimate the number of conformational epitopes on the 60-kD Ro antigen. Anti-Ro Fab or Fab′ was incubated with native Ro antigen at different ratios and the Stokes radius molecular weight of complexes was estimated by gel filtration. Binding was saturated at 9 to 11 Fab molecules per bovine Ro molecule. Two additional Fab or Fab′ were bound if human Ro was used as the antigen. Isolated Ro antigen/anti-Ro Fab complexes were evaluated for the relative proportion of antigen to antibody at saturation of antigen with antibody and thus stoichiometry was determined. This provided data supporting there being between 7 and 11 binding sites, results similar to those with the gel filtration method. Experiments carried out with anti-Ro monoclonal antibodies showed one binding site per molecule of 60-kD Ro. Therefore, we have developed methods to count conformational epitopes on autoantigens and have applied it to the Ro/anti-Ro system. The data indicate that multiple conformational epitopes can be bound simultaneously by polyclonal anti-Ro sera from patients with systemic lupus erythematosus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027354327344
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis of crowned initiators and kinetic studies of crowned benzophenone-sensitized photopolymerization of methyl methacrylate (1993)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 194 (1993), S. 1847-1862 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A series of crowned benzophenones (CBPs) and benzoins was synthesized. Application of CBPs as initiators for the photopolymerization of methyl methacrylate (MMA) indicated a kinetic similarity between benzophenones and crowned benzophenones. With CBPs a rate enhancement was observed which was attributed to the higher light absorptance in the presence of crown ether structure. UV spectra confirmed the existence of the crown species as end groups of the polymer chains.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1993.021940630
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A method to determine shear adhesive strength of fibrin sealants (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 3 (1992), S. 147-151 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The adhesive strength of fibrin sealants has not been rigorously evaluated to date. The adhesive strength of six different concentrations of cryoprecipitated fibrinogen as well as the commercially available fibrin tissue adhesive Tissucol® was tested under controlled conditions utilizing split-thickness skin grafts as the test adherand. This test configuration permitted the modeling of bonding strength for attachment of skin grafts as well as incorporate established engineering test standards for adhesives. An increase in fibrin concentration corresponded with an increase in shear adhesive strength. No significant increases in adhesive strength were attained after 5 min of bonding for all tested concentrations, except for the commercial adhesive, which attained the adhesive strength of an equivalent concentration of cryoprecipitated adhesive after 90 min. The adhesive strength, however, was an order of magnitude less than reported values of the tensile strength of fibrin material for similar concentrations. Therefore, it is important that the surgeon use a sufficiently high fibrinogen concentration for the specific clinical indication. The method of fibrin sealant preparation and/or the compounding adjuncts appear to have an effect on the development of adhesive strength.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770030210
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    HPLC analysis of polycarbonate oligomers and its process applications in the interfacial phosgenation reaction (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 40 (1990), S. 555-567 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A liquid chromatographic method for the oligocarbonates and chloroformate-containing oligomers at various stages in a typical polycarbonate phosgenation reaction has been developed. The accurate measurement of various types oligomers during phosgenation should allow for a better understanding of polymerization mechanism and provide great aid in defining the critical process parameters. Comparison of the total choloroformate concentration by accumulating every individual chlorofor-mate-containing componenent and the standard colorimetric method shows close agreement.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1990.070400321
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    Paper (German National Licenses)
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