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  • Polymer and Materials Science  (4)
  • gastrointestinal transit in rats  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Measurement of circular dichroism using a thin cell (1976)
    New York : Wiley-Blackwell
    Biopolymers 15 (1976), S. 591-594 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1976.360150315
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Conformational analysis of somatostatin and selected analogs in oriented polyoxyethylene by infrared dichroism (1980)
    New York : Wiley-Blackwell
    Biopolymers 19 (1980), S. 341-352 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Infrared dichroic studies and deuterium exchange measurements of somatostatin and some of its analogs incorporated in uniaxially oriented polyoxyethylene are described. Band positions and dichroic ratios in the N-H stretching and amide I and II regions are similar to those of flexible and nonordered peptides like valinomycin and poly[Glu(ONa)]. This information, together with fast deuterium exchange rates, suggests that somatostatin exists in a flexible nonordered conformation in polyoxyethylene. One analog, di-S3,14-acetamidomethyl dihydrosomatostatin, was found to exist in both nonordered and β-like conformations.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1980.360190211
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of substance P on Rat gastrointestinal transit (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 74-77 
    Details
    ISSN: 1573-2568
    Keywords: substance P ; gastrointestinal transit in rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thein vivo effect of substance P and related peptide analogs on gastrointestinal transit in unanesthetized rats was studied. Fasted male rats were given intragastrically 0.5 ml of a powdered charcoal (BaSo4·H2O) meal and were concomitantly injected intraperitoneally with 8 Μg/kg of substance P or a related peptide. In control rats, the percentage of small intestine traversed by the meal 15 min after feeding was 44.9±1.4 (N = 12). Substance P, [Glu6]SP6–11, [pGlu6, gPhe6, mGly9]SP6–11 and [pGlu5,N-MePhe8,N-MeGly9SP6–11, significantly accelerated intestinal transit: 59.5±3.1% (N=7); 66.0±3.8% (N=14), 66.8±2.4% (N=25), and 58.4±4.4% (N=4), respectively. Concomitant injection of [pGlu6SP6–11 and BOC-Phe-Phe-Gly-NHOH, an inhibitor of enzyme degradation at a dose of 800 Μg/kg lowered by 10-fold the dose of [pGlu6]SP6–11 needed to induce the same degree of intestinal transit acceleration. These results indicate that in rats, substance P and related peptides accelerate gastrointestinal transit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536634
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Specific aggregations of alanine tetrapeptide derivatives as studied by nuclear magnetic resonance (1975)
    New York : Wiley-Blackwell
    Biopolymers 14 (1975), S. 915-925 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: By use of high resolution nuclear magnetic resonance and infrared spectroscopy, we have found evidence for specific folded forms for the methoxyethoxyethoxyacetyl-blocked alanine tetramer ethyl ester. It appears that this tetrapeptide derivative exists in a folded form which is in rapid equilibrium with an extended structure (i.e., below 1% w/v). At high concentrations (i.e., above 1% w/v in chloroform) the folded form is stabilized by an association of the alanine tetrapeptide derivative into a side-by-side dimer which contains specific hydrogen bonds between the amine terminal regions of the two folded structures.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1975.360140503
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Conformational studies of peptides. The crystal structures of N-acetyl-L-prolinamide and N-acetyl-(S)-thiazolidine-4-carboxamide (1976)
    New York : Wiley-Blackwell
    Biopolymers 15 (1976), S. 2523-2534 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The crystal structure of N′-acetyl-L-prolinamide and its isomorphous alalog N′-acetyl-(S)-thiazolidine-4-carboxamide was determined using highly accurate parameters obtained by room- and low-temperature data-collecting systems. Both crystals are orthorhombic, space group P212121, with four molecules per unit cell held together by a hydrogen-bond system that extends in all directions.Both molecules exhibit the following conformational features: the acetyl group is in the trans configuration in respect to the tertiary amide. The primary amide is almost at right angles with respect to the mean plane of the ring and the -NH2 group is over the ring. The pyrrolidine and thiazolidine rings were found to be rather flexible with Cβ puckering in the former and sulfur in the latter.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1976.360151213
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    Paper (German National Licenses)
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