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  • 1
    Electronic Resource
    Electronic Resource
    Adhesion behavior of rat lymphocytes on poly(γ-benzyl L-glutamate) derivatives having hydroxyl groups or poly(ethylene glycol) chains (1984)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 185 (1984), S. 2109-2116 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Poly[γ-benzyl L-glutamate (BLG)-co-N5-(3-hydroxypropyl)-L-glutamine (HLG)] (3) and polyBLG/poly(ethylene glycol) (PBLG/PEG) block copolymers (6) were synthesized, and the adhesion behavior of rat lymphnode lymphocytes on these polymers was examined by the column method. An increase in the HLG content of polymer 3 caused a slight decrease in lymphocyte adhesivity. Lymphocyte subpopulation B cells were found to be more adhesive to polymers 3 than T cells, by a factor of 1,4 - 1,6. On the other hand, an increase in the PEG content of PBLG/PEG block copolymer caused a remarkable decrease inlymphocyte adhesivity and an increase in selectivity in the adhesivity between B cells and T cells up to a factor of 2,3.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1984.021851006
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of interaction between constituent blocks on conformation of the ABA type 2-hydroxyethyl methacrylate/styrene block copolymer in a solvent mixture (1981)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 182 (1981), S. 2039-2047 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The ABA type block copolymer of 2-hydroxyethyl methacrylate (HEMA) and styrene was synthesized and the influence of the interaction between constituent blocks on the conformational change of the block copolymer was investigated in mixtures of DMF and 1,4-dioxane which are selective solvents for poly(HEMA) and polystyrene, respectively. The intrinsic viscosity [η] of the mixture from the parent homopolymers of the block copolymer was compared with the value calculated on assuming lack of interaction between unlike segments. The [η] value at 15°C was found to agree with the calculated value despite of incompatibility between dissimilar segments. On the contrary, the [η] value at 30°C deviated positively from the theoretical value, especially in N,N-dimethylformamide (DMF) or 1,4-dioxane-rich solvents, indicating that hetero contact between unlike segments at elevated temperature results in an increase of the average hydrodynamic volume because of repulsive interaction. The molecular expansion was found to become large with an enhancement of incompatibility. The same kind of transition versus temperature was observed in the intrinsic viscosity curve of the block copolymer, suggesting that hetero contacts between dissimilar segments occur at elevated temperature and that enhancement of solvent selectivity results in a conformational change of the block copolymer. A further increase of the solvent selectivity toward the polystyrene blocks was found to lead to intermolecular association of the block copolymer through aggregation of the poly(HEMA) side blocks.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1981.021820716
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular design for missile drug: Synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol)-block-poly(aspartic acid) as intermediate carrier (1989)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 190 (1989), S. 2041-2054 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Synthesis of a novel conjugate of anticancer drug adriamycin, poly(ethylene glycol)-block-poly(aspartic acid), and immunoglobulin G is reported. Poly(ethylene glycol)-block-poly(aspartic acid), binding adriamycin on the poly(aspartic acid) chain, showed an excellent water-solubility despite the introduction of a large amount of strongly hydrophobic adriamycin, and was found to form a micellar structure in aqueous solution. Efficient coupling between poly(ethylene glycol)-block-poly(aspartic acid) binding adriamycin and immunoglobulin G was achieved via disulfide linkages.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1989.021900904
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis of a new antithrombogenic block copolymer containing fluorinated segments: poly(nonafluorohexyl acrylate-b-styrene)Dedicated to Prof. Dr. Teiji Tsuruta on the occasion of his 65th birthday (1986)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 187 (1986), S. 1627-1638 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Two types of block copolymers, 3a and 3b, were synthesized from α-hydro-ω-(2-hydroxyethylthio)poly[1-(3,3,4,4,5,5,6,6,6-nonafluorohexyloxycarbonyl)ethylene] (1a) or α-hydro-ω-(2-aminoethylthio)poly[1-(hexyloxycarbonyl)ethylene] (1b) and α,ω-bis(4-cyanatophenylthio)-poly(1-phenylethylene) (2), respectively, and the adhesion of blood platelets to these polymer surfaces was evaluated. Adhesion and activation of platelets were found to be effectively suppressed at the lamellar-microdomain surface of block copolymer 3a, having a surface free energy gap between microdomains of about 20 dyn/cm, whereas no such a suppression was observed for the microdomain structured surface of block copolymer 3b with a small surface free energy gap between the microdomains. Further, a random copolymer from nonafluorohexyl acrylate and styrene without microdomain structure does not suppress the adhesion and activation of platelets. From these results, it was concluded that the microdomain morphology and the surface free energy gap between microdomain is important to produce antithrombogenicity.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1986.021870707
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of SPUU-PEO-heparin graft copolymers (1991)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 29 (1991), S. 1725-1737 
    Details
    ISSN: 0887-624X
    Keywords: (heparin-PEO) grafted segmented polyurethaneurea ; surface modification ; nonthrombogenic surface ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new synthetic approach for the preparation of segmented polyurethaneurea (SPUU)-PEO-Heparin graft copolymers (B-PEO-Hep) has been developed. The procedure involved the coupling of hexamethylene diisocyanate (HMDI) to soluble Biomer® (B) through an allophanate/biuret reaction. The free isocyanate (NCO) groups attached to Biomer® were then coupled to PEO terminal hydroxyl groups to form PEO grafted Biomer® (B-PEO). B-PEO free hydroxy groups were modified with HMDI to introduce terminal isocyanate groups. The NCO functionalized B-PEO was then coupled to heparin (Hep) functional groups (—OH, —NH2) producing B-PEO-Hep graft copolymer. Synthetic intermediates were confirmed by FTIR, NCO group determination, and toluidine blue heparin assay. Physical characterization techniques, such as contact angle measurements, water swelling, light scattering measurements, and DSC thermal analysis, detailed properties of the graft copolymer containing covalently bound heparin. This new heparinized copolymer can be applied as a coating on other existing blood contacting surfaces without changing bulk properties. The heparin bioactivity observed attests to the usefulness of this new procedure as a coating to improve the blood compatibility of blood-contacting surfaces.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1991.080291206
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  • 6
    Electronic Resource
    Electronic Resource
    Temperature dependence of swelling of crosslinked poly(N,N′-alkyl substituted acrylamides) in water (1990)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 28 (1990), S. 923-936 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The swelling of crosslinked poiy(N,N′-alkyl substituted acrylamides) in water was studied in relation to temperature changes. Conventional swelling theory and separation of the polymer solvent interaction parameter into enthalpic and entropic contributions were used to characterize the temperature dependence of swelling in water. The thermosensitivity of swelling can be attributed to the delicate hydrophilic/hydrophobic balance of polymer chains and is affected by the size, configuration, and mobility of alkyl side groups. A sharp swelling transition may occur at an optimum hydrophilic/hydrophobic balance but was found only in the N-isopropylacrylamide network among the networks tested. This swelling transition pattern was also reflected by the endothermic peak of the DSC thermogram of the swollen sample.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1990.090280609
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of the incorporation of amino groups in a glucose-responsive polymer complex having phenylboronic acid moieties (1991)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 2 (1991), S. 261-264 
    Details
    ISSN: 1042-7147
    Keywords: Polymer complex ; diabetes ; phenylboronic acid ; stimuli-responsive polymer drug delivery system ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel polymer complex system sensitive to glucose was studied as a candidate material for formulating a chemically regulated insulin release system. A ternary copolymer of N-vinyl-2-pyrrolidone (NVP), 3-acrylamidophenylboronic acid (AAm-PBA) and N,N-dimethylaminopropylacrylamide (DMAPAA) (poly(NVP-co-PBA-co-DMAPAA)) was synthesized by radical copolymerization. The phenylboronic acid group in this copolymer serves as a glucose sensor moiety. Poly(NVP-co-PBA-co-DMAPAA) was soluble in water in the pH range of 3-12, in sharp contrast to a binary copolymer of NVP and AAm-PBA (poly(NVP-co-PBA)) which showed solubility only under alkaline aqueous conditions, where the boronic acid group is in a tetrahedral ionized form. The protonated amino group in poly(NVP-co-PBA-DMAPAA) contributed to increase the solubility of the polymer under physiological and acidic aqueous conditions. Furthermore, poly(NVP-co-PBA-co-DMAPAA) formed a stable polymer complex gel with poly(vinyl alcohol) (PVA) in pH 7.4 phosphate buffered solution due to the formation of a covalent linkage between the boronic acid groups in ternary copolymer and diol units in PVA. The release of myoglobin as model protein from the complex gel was increased immediately after the addition of glucose, due to the transition of gel into sol state, indicating the feasibility of this complex gel as a candidate material for a glucose-responsive delivery system for insulin.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1991.220020508
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  • 8
    Electronic Resource
    Electronic Resource
    Thermal and structural analysis of heparin-PEO-PDMS-PEO-heparin pentablock copolymers (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 54 (1994), S. 1863-1872 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: ABCBA-type amphiphilic block copolymers comprising polydimethylsiloxane (PDMS), poly(ethylene oxide) (PEO), and heparin segments were synthesized by coupling reactions between end-functionalized oligomers. These multiblock copolymers were characterized to examine bulk properties using 1H-NMR, FTIR, end-group analysis, and sulfur elemental analysis. Block copolymers were further characterized in bulk using differential scanning calorimetry and X-ray diffraction measurements. The PDMS glass transition remains unchanged with increasing PEO content, indicating coexistence of pure PDMS with mixed phases. Furthermore, endothermic melting of the block copolymers shifts to higher temperatures and becomes more intense with increasing PEO molecular weight. Additionally, the crystallinity of the PEO segment in the block copolymers increases with increasing PEO molecular weight. The PEO melting endotherm peak shifts from near 318 to 323 K with annealing. In the cooling thermogram, the block copolymers exhibit two crystallization exotherms, one near 303 K and the other near 193 K, attributed to PEO and PDMS recrystallization and nucleation, respectively. © 1994 John Wiley & Sons, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1994.070541209
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  • 9
    Electronic Resource
    Electronic Resource
    Cellular affinity of polyamides having various functional groups. I. Platelet adhesionManuscript complete January 25, 1981 (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 26 (1981), S. 2293-2303 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Various polyamides having a different density of hydrogen bonding, of hydrophilic character, and containing ionic groups have been synthesized and their blood compatibilities were evaluated in terms of the adhesion behavior of blood platelets on polyamide by the microsphere column method. Polyamides containing anionically charged groups such as carboxylate or sulfonate groups adsorbed fewer blood platelets than those with undissociated carboxylate groups. Polyamides having thioether groups adsorbed fewer platelets than those having ether groups. Introduction of a rigid piperazine unit caused an increase in platelet adhesion.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1981.070260716
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of crystallinity of condensation polymers on platelet adhesion (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 26 (1981), S. 4207-4216 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Various polyamides and polyesters having different numbers of methylene groups in their repeating units have been synthesized and their blood compatibilities have been evaluated in terms of the adhesion behavior of blood platelets on the surface of these condensation polymers by a micro-sphere-column method. The number of methylene groups in the repeating units of polyamides and polyesters influenced the adhesion behavior of platelets and there was an optimum number of methylene groups each in polyamides and polyesters. Poly(hexamethylene terephthalamide) and poly(pentamethylene terephthalate) adsorbed platelets in the smallest number in the polyamide and polyester series, respectively. Blood platelets were adsorbed on polyamides in smaller numbers than on corresponding polyesters. It was found that the platelet adhesion on the surface of polyamides and polyesters was closely related to their crystallinities and the number of the adsorbed platelets decreased linearly with increasing their relative crystallinity.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1981.070261221
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