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  • 1
    Electronic Resource
    Electronic Resource
    Non-invasive measurement of left ventricular volumes and function by gated positron emission tomography (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 1594-1602 
    Details
    ISSN: 1619-7089
    Keywords: Left ventricular volumes ; Left ventricular function ; Positron emission tomography ; Gating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To date cardiac positron emission tomography (PET) studies have focussed on the measurement of myocardial blood flow, metabolism and receptors while left ventricular (LV) function and dimensions have been derived from other modalities. The main drawback of this approach is the difficulty of data co-registration, which limits clinical interpretation. The aim of this study was to evaluate whether it is possible to measure absolute cardiac volumes, and consequently LV function parameters such as ejection fraction, and wall motion with gated PET. Nineteen patients underwent a PET scan and planar radionuclide ventriculography (MUGA) within 9±9 days. A 9-min scan (16 gates/cardiac cycle) was acquired after inhalation of 3 MBq/ml of oxygen-15 labelled carbon monoxide at the rate of 500 m1/min over 4 min using a multislice PET camera. Noise reduction was performed on the gated image to enhance the definition of the ventricles before reslicing to the short-axis view. A threshold value was used to detect the edge of the LV at each gate. LV volumes at each gate were estimated by summing the volume of voxels within the LV boundary. PET measurements of LV volumes were as follows: LV end-diastolic volume ranged from 72 to 233 ml and LV end-systolic volume ranged from 24 to 203 ml. Phantom experiments supported the validity of this approach for estimating volumes. LV ejection fraction measured with MUGA was 38.4%±16.3% (range 15%–71%) and that measured with PET was 39.6%±17.7% (range 9%–72%) (P=NS). The LV ejection fraction measurements were highly correlated (r 2=0.824). These results indicate that: (1) absolute enddiastolic and end-systolic volumes can be quantified using gated PET and (2) LV ejection fraction can be accurately measured by gated PET simultaneously with the other physiological PET parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249622
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transmission scanning in emission tomography (1998)
    Springer
    European journal of nuclear medicine 25 (1998), S. 774-787 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Attenuation correction ; Transmission scans ; Single-photon emission tomography ; Positron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Attenuation correction in single-photon (SPET) and positron emission (PET) tomography is now accepted as a vital component for the production of artefact-free, quantitative data. The most accurate attenuation correction methods are based on measured transmission scans acquired before, during, or after the emission scan. Alternative methods use segmented images, assumed attenuation coefficients or consistency criteria to compensate for photon attenuation in reconstructed images. This review examines the methods of acquiring transmission scans in both SPET and PET and the manner in which these data are used. While attenuation correction gives an exact correction in PET, as opposed to an approximate one in SPET, the magnitude of the correction factors required in PET is far greater than in SPET. Transmission scans also have a number of other potential applications in emission tomography apart from attenuation correction, such as scatter correction, inter-study spatial co-registration and alignment, and motion detection and correction. The ability to acquire high-quality transmission data in a practical clinical protocol is now an essential part of the practice of nuclear medicine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050282
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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