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Digitale Medien

Pharmacokinetics of dextro-, leavo- and racemic propranolol in man (1972)

George, C. F. ; Fenyvesi, T. ; Conolly, M. E. ; [weitere]

Springer

European journal of clinical pharmacology 4 (1972), S. 74-76

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Details

ISSN: 1432-1041

Schlagwort(e): Propranolol ; optical isomers

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Late plasma half-lives of dextro and racemic propranolol were measured in seven adult male subjects after 100 mg taken orally. Mean plasma half-lives of 2.38±0.43 and 2.93±0.63 h were obtained for dextro and racemic preparations respectively. In five of these subjects plasma half-lives after 50 mg dextro and laevo isomers were 2.02±0.53 and 3.20±0.42 h. No difference was found in the rates of absorption of the two isomers It is concluded that these results reflect either differences in distribution or a slower rate of metabolism of the laevo isomer.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00562500

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