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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of dextro-, leavo- and racemic propranolol in man (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 74-76 
    Details
    ISSN: 1432-1041
    Keywords: Propranolol ; optical isomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Late plasma half-lives of dextro and racemic propranolol were measured in seven adult male subjects after 100 mg taken orally. Mean plasma half-lives of 2.38±0.43 and 2.93±0.63 h were obtained for dextro and racemic preparations respectively. In five of these subjects plasma half-lives after 50 mg dextro and laevo isomers were 2.02±0.53 and 3.20±0.42 h. No difference was found in the rates of absorption of the two isomers It is concluded that these results reflect either differences in distribution or a slower rate of metabolism of the laevo isomer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562500
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