ISSN:
1432-1041
Keywords:
Idiopathic nephrolithiasis
;
glycosaminoglycans
;
red cell oxalate selfexchange
;
red cell membrane protein phosphorylation
;
Sulodexide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Oral administration of mixture of extractive glycosaminoglycans to a group of renal stone formers led to a significant decrease in oxalate self-exchange and in erythrocytes membrane protein phosphorylation traits that are abnormal in the majority of patients with idiopathic calcium nephrolithiasis. The action of glycosaminoglycans at the cellular level is probably due to their modulating activity on certain membrane protein kinases. The proven effect of the glycosaminoglycans opens a new pharmacological approach to the prevention of recurrent nephrolithiasis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315202
Permalink