ISSN:
0749-1581
Keywords:
1H NMR
;
13C NMR
;
19F NMR
;
NOESY
;
2D NMR
;
NMR assignments
;
Spiperone conformation in solution
;
Proton relaxation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The high-field 1H, 19F and 13C NMR spectra of spiperone in CDCl3 solution were analyzed with the aid of homonuclear (H-H-COSY) and heteronuclear (H,C-COSY) chemical shift correlation experiments. Multiple through-space intersections were identified using phase-sensitive nuclear Overhauser and exchange spectroscopy (NOESY). Proton relaxation rates and activation energies were determined over the temperature range -60 to 50°C. The chemical shift, NOESY and proton relaxation rate results support the formation of cyclic dimers and multiple spiperone conformations in solution.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260310609
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