ISSN:
1572-8773
Keywords:
iron
;
ornibactin
;
Pseudomonas
;
pyoverdines
;
siderophores
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Novel linear hydroxamate/hydroxycarboxylate siderophores from strains of Pseudomonas cepacia were isolated and named ornibactins. The ornibactins represent modified tetrapeptide siderophores, possessing the sequence l-Orn1(N δ-OH, N Δ-acyl)-d-threo-Asp(β-OH)-l-Ser-l-Orn4(N δ-OH, N δ-formyl)-1,4-diaminobutane. The N δ-acyl groups of Orn1(N δ-OH, N δ-acyl) may vary and represent the three acids 3-hydroxybutanoic acid, 3-hydroxyhexanoic acid and 3-hydroxyoctanoic acid, leading to a mixture of three different ornibactins, designated according to their acyl chain length as ornibactin-C4, ornibactin-C6 and ornibactin-C8. Each of the siderophores is accompanied by a small amount of a more hydrophilic component with a 16 a.m.u. higher mass. The structure elucidation was based on results from gas chromatography amino acid analysis, electrospray mass spectrometry, and one- and two-dimensional nuclear magnetic resonance techniques.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00140109
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