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  • 1
    Electronic Resource
    Electronic Resource
    Augmented glucose-6-phosphate dehydrogenase activity and normal penetration and metabolism of dehydroepiandrosterone in mononuclear leukocytes in psoriasis (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 393-397 
    Details
    ISSN: 1432-069X
    Keywords: Glucose-6-phosphate dehydrogenase ; Dehydroepiandrosterone ; Mononuclear leukocytes ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the study was to determine a biochemical basis for the augmented oxidative metabolism found in mononuclear leukocytes (MNL) of patients with active psoriasis. Dehydroepiandrosterone (DHEA) is known to inhibit glucose-6-phosphate dehydrogenase (G-6-PDH). We determined the activity of G-6-PDH as well as the penetration and metabolism of DHEA — diminished plasma concentrations of which have been found in psoriatics previously — in 16 patients with active psoriasis and 16 controls. MNL in patients with psoriasis possessed 52% more (p〈0.05) G-6-PDH activity, based on cell number, and 34% more (p〈0.05) activity, based on soluble protein. No difference in DHEA penetration and metabolism in MNL was found between psoriatics and controls, in contrast with previous findings of reduced penetration and increased reduction in erythrocytes of psoriatics. We conclude that the enhanced G-6-PDH activity in MNL of patients with active psoriasis is not due to altered DHEA penetration or metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418169
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  • 2
    Electronic Resource
    Electronic Resource
    Radioimmunologische Bestimmung von Dehydroepiandrosteron und 5-Androsten-3ß,17ß-diol im Plasma von Psoriatikern und Kontrollpersonen (1979)
    Springer
    Archives of dermatological research 266 (1979), S. 181-185 
    Details
    ISSN: 1432-069X
    Keywords: Radioimmunoassay ; Dehydroepiandrosterone ; Androstene-diol ; Psoriasis ; Radioimmunologische Bestimmung ; Dehydroepiandrosteron ; Androstendiol ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mittels radioimmunologischer Bestimmungsverfahren wurden die Steroide Dehydroepiandrosteron und 5-Androsten-3ß,17ß-diol im Plasma von Psoriatikern und Kontrollpersonen bestimmt. Entsprechend den bereits früher mit photometrischen Methoden erhobenen Befunden war bei den Psoriatikern der Plasma-Spiegel des Dehydroepiandrosterons erniedrigt und der des Androstendiols erhöht.
    Notes: Summary In the plasma of psoriatics and controls the steroids dehydroepiandrosterone and 5-androstene-3ß,17ß-diol were determined by radioimmunoassay. Corresponding earlier findings obtained by photometric methods in psoriatics the plasma level of dehydroepiandrosterone is increased and that of androstenediol is decreased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694627
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  • 3
    Electronic Resource
    Electronic Resource
    Etretinate or cyclosporin-A treatment normalizes the enhanced respiratory burst of polymorphonuclear leukocytes in psoriasis (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 227-231 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Polymorphonuclear leukocytes ; Etretinate ; Cyclosporin A ; Chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During a therapeutic trial to treat psoriasis with either etretinate or cyclosporin A (CyA) we measured the respiratory burst activity of polymorphonuclear leukocytes (PMN). Six patients received 0.5–0.75 mg/kg etretinate and 14 patients 2.5–5.0 mg/kg CyA over a period of 10 weeks. The extent of psoriasis was graded by the psoriasis area-and-severity index (PASI score). The respiratory burst of PMN isolated from the peripheral blood was measured employing luminol-enhanced chemiluminescence at weeks 0, 3 and 10 and compared with that of 26 healthy control individuals. PMN were stimulated with zymosan particles, aggregated immunoglobulin (aggIg) and concanavalin A (ConA). Both treatment regimens improved psoriasis; at 10 weeks there was an approximate 40% PASI score reduction under etretinate and an 80% improvement under CyA. Before treatment the respiratory burst was abnormally high under stimulation with the three stimuli in patients (p=0.021 to〈0.0001). After 3 to 10 weeks PMN activity normalized in all patients and even tended to drop below values correlating with an improvement in skin lesions. We conclude that the elevated respiratory burst of PMN in psoriasis normalizes under treatment with both etretinate and CyA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375799
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Penetrationskinetik von Dehydroepiandrosteron durch die Erythrocytenmembran (1981)
    Springer
    Archives of dermatological research 270 (1981), S. 49-55 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Dehydroepiandrosterone ; Penetration kinetics ; Erythrocytes ; Psoriasis ; Dehydroepiandrosteron ; Penetrationskinetik ; Erythrocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei zehn Kranken mit Psoriasis vulgaris und zehn Kontroll-personen wurde die Penetrationskinetik von freiem Dehydroepiandrosteron (DHEA) durch die Erythrocytenmembran und der Metabolismus des penetrierten DHEA untersucht. Entsprechend früheren Befunden ist die Penetration des DHEA bei Psoriatikern erniedrigt und der intraerythrocytäre Stoffwechsel zugunsten einer verstärkten Reduktion dieses Steroids verschoben. Bei Psoriatikern und Kontrollpersonen ergab sich weiterhin eine lineare Abhängigkeit der Penetration von DHEA in den Erythrocyten von der DHEA-Konzentration im Inkubationsmedium. Dieser Befund weist am ehesten auf eine passive Diffusion dieses Steroids durch die Zellmenbran hin.
    Notes: Summary In ten patients with psorasis and ten controls the penetration kinetics of free dehydroepiandrosterone (DHEA) through the erythrocyte membrane and the metabolism of penetrated DHEA was studied. Corresponding to former findings in psoriatics the penetration of DHEA is decreased and the metabolism in the erythrocyte is shifted to an increased reduction of DHEA. Furthermore, in psoriatics and controls there was a positive correlation between the DHEA penetration through the erythrocyte membrane and the DHEA concentration outside the cell. These data point to a passive diffusion of DHEA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417149
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  • 5
    Electronic Resource
    Electronic Resource
    Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis (1986)
    Springer
    Archives of dermatological research 279 (1986), S. 89-94 
    Details
    ISSN: 1432-069X
    Keywords: Autologous T cells ; Epidermis cells ; Proliferation ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clinically uninvolved skin in psoriasis (autologous mixed epidermal cell lymphocyte reaction, AMECLR). Age- and sex-matched individuals served as controls. We found that the AMLR in psoriasis (n=11) was similar to that in healthy controls (n=16); furthermore, cell proliferation was alike in the presence of either 5% AB-serum or autologous serum. By contrast, while the AMECLR in healthy controls (n=9) resembled that in psoriatics employing epidermal cells from univolved skin, epidermal cells from lesional sites (n=10) induced a significantly higher proliferation of autologous T cells in the AMECLR (P〈0.01). We conclude that the in vitro stimulation of T cells by non-T mononuclear leukocytes is normal in psoriasis and is not regulated by autologous serum. Lesional psoriatic epidermal cells, however, are more active in stimulating autologous T cell proliferation than cells from univolved psoriatic or normal epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417528
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  • 6
    Electronic Resource
    Electronic Resource
    Enhanced procoagulant acticity of mononuclear leukocytes in patients with atopic dermatitis and psoriasis (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 305-309 
    Details
    ISSN: 1432-069X
    Keywords: Mononuclear leukocytes ; Procoagulant activity ; Atopic dermatitis ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fibrin deposition is an important histopathological feature of inflammatory skin lesions and is mediated in part, by procoagulants generated by mononuclear leucocytes (MNL). We examined whether MNL from patients with atopic dermatitis or psoriasis generate enhanced procoagulant activity (PCA). MNL isolated from the peripheral blood of 15 healthy control individuals, 15 patients with atopic dermatitis and 15 patients with psoriasis were incubated for 24 h in the presence or absence of bacterial lipopolysaccharide (LPS). MNL or the cell culture supernatants were then added to recalcified human plasma to determine the clotting time. We found that in both atopic dermatitis and psoriasis MNL cultured in the presence or absence of LPS expressed greatly enhanced PCA (p〈0.01 to 〈0.002). Supernatants from MNL cultures from patients with psoriasis, but not those from patients with atopic dermatitis, also generated augmented PCA (p〈0.002). In psoriasis, PCA normalized after successful topical treatment with anthralin. We conclude that enhanced PCA is a characteristic feature of MNL in both atopic dermatitis and psoriasis. In psoriasis the enhanced PCA is directly related to disease activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371602
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