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  • cold-restraint stress  (3)
  • Pyloric Ligation  (1)
  • gastric function  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The influence of chronic nicotine treatment on stress-induced gastric ulceration and emptying rate in rats (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 389-391 
    Details
    ISSN: 1420-9071
    Keywords: Nicotine ; cold-restraint stress ; gastric ulcers and motility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ten-day treatment with nicotine, (5, 25 or 50 μg/ml drinking water) dose-dependently intensified gastric ulceration induced by cold-restraint, and emptying rate. Stomach contractions produced by graded doses of bethanechol i.v. were elevated further by nicotine treatment. It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923437
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nitric oxide inhibition intensifies cold-restraint induced gastric ulcers in rats (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 304-307 
    Details
    ISSN: 1420-9071
    Keywords: NW-nitro-l-arginine methyl ester ; nitric oxide ; cold-restraint stress ; mucosal ulcers ; mast cells ; rat stomachs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Treatment 20 min beforehand with an inhibitor of nitric oxide (NO) synthesis, NW-nitro-l-arginine methyl ester (L-NAME) (12.5, 25, 50 or 100 mg/kg, s.c.), dose-dependently intensified gastric glandular mucosal ulceration produced by cold-restraint stress. Hexamethonium (20 mg/kg) or atropine (1 mg/kg) pretreatment s.c. 20 min before stress strongly antagonised stress-evoked ulceration, as well as the ulcer-potentiating effects of L-NAME when either cholinoceptor antagonist was given concurrently with the NO inhibitor. Stress-induced mast cell degranulation was not worsened by L-NAME pretreatment. The findings suggest that NO could confer partial protection against stress-induced gastric ulcer formation; its activity is triggered off by the ulcerogenic mechanism of stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923407
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The influence of peripheral or central administration of ondansetron on stress-induced gastric ulceration in rats (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 786-789 
    Details
    ISSN: 1420-9071
    Keywords: Ondansetron ; 5-hydroxytryptamine3 receptors ; cold-restraint stress ; mucosal ulcers ; mast cells ; rat stomachs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ondansetron (0.08, 0.15 or 0.3 mg/kg) injected s.c., every 12h with the fourth dose given 0.5 h before experiments, dose-dependently lessened gastric glandular mucosal ulceration produced by cold-restraint stress for 2h. When given intracerebrally (i.c.) (0.1, 0.5 or 1μg), using the same treatment regimen, infusion of ondansetron 1 μg into the nucleus amygdaloideus centralis decreased stress-evoked ulcers; in contrast, injection of the same dose into the nucleus accumbens intensified these lesions. The associated stress-induced stomach wall mast cell degranulation was unaffected by all s.c. or i.c. doses of ondansetron. Pretreatment with disodium cromoglycate i.p. alone, or concurrently with ondansetron s.c., prevented not only ulceration but also mast cell degranulation. 5-Hydroxytryptamine3 receptor antagonism appears to inhibit stress-evoked ulcers mainly by blocking the peripheral effects of the amine after its release from the gastric mucosal mast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922431
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A new method for the collection of gastric secretion in conscious rats (1972)
    Springer
    Pflügers Archiv 336 (1972), S. 111-120 
    Details
    ISSN: 1432-2013
    Keywords: Gastric Secretion ; Pyloric Ligation ; Conscious Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new method has been devised for the collection of gastric secretion in conscious rats. A stainless steel wire loop was placed around the pylorus. Seven to 10 days later when the rat had recovered from the operation and was showing significant weight gains and food intake, it was starved for 48 h and collection of gastric juice was begun by tightening the wire loop. This effectively occluded the pylorus, and had the advantage that the animal remained conscious during the procedure. The rat was sacrificed after a certain period of time, and the gastric content was collected. After centrifugation, the total acidity of the supernatant was determined by titration with 0.01 N NaOH. With the present method, the total acid output as well as the rate of gastric secretion were significantly higher than those of similarly operated rats under restraint and those which were investigated using the Shay method. The gastric mucosa of each rat was examined and it was found that the incidence of gastric lesions in the control group using the present method was significantly lower than that in the other operated groups. This method is regarded as less unphysiological than the widely used Shay technique, in which pyloric ligation is performed in the unconscious rat immediately before the collection of gastric juice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592926
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Portal hypertension (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 2203-2208 
    Details
    ISSN: 1573-2568
    Keywords: portal hypertension ; gastric function ; ethanol ; gastric damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time-course effects of portal hypertension on gastric secretory function, mucosal blood flow, vascular permeability, and ethanol-induced gastric mucosal damage were examined in anesthetized rats. Partial ligation of the portal vein effectively produced portal hypertension one to three days later but the raised pressure returned to normal on the sixth day after ligation. This time-course effect coincided with reduced pepsin secretion and mucosal blood flow and also with potentiated ethanol-induced mucosal damage during the first to third days. These effects started to tail off on the sixth day. However, gastric acid output was significantly reduced on the third day, and this was strongest on the sixth day after operation. Portal vein ligation also reduced basal vascular permeability, which was markedly potentiated after ethanol treatment. It is concluded that: (1) portal vein blood pressure changes are a time-dependent process following ligation; (2) changes in gastric mucosal blood flow (GMBF) and lesion formation are closely related to portal hypertension; (3) gastric mucosal injury is associated with vascular damage, as evidenced by increased in vascular permeability; and (4) pepsin but not acid secretion is closely related to the state of the GMBF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299896
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    Paper (German National Licenses)
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