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  • 1
    ISSN: 1432-1335
    Keywords: Cell line ; Radiation-induced osteosarcoma ; Mice ; C-type RNA virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eight cell lines were established from murine osteosarcomas induced in vivo with the radionuclides 224Ra and 227Th. They have been compared by light and electron microscopy, by karyology, and by their growth properties. The morphology, the growth pattern, and the ability to induce tumors in mice indicate that five of them are tumor cell lines. Chromosome studies demonstrated that the five cell lines have marker chromosomes. The other cell lines only showed some criteria generally used to score for transformation of fibroblasts and they may be derived from stromal cells. All cell lines release virus particles in the culture fluid which have the typical properties of RNA tumor viruses. They possess C-type morphology, a density of 1.16–1.18 g/cm3, a 60–70 S RNA, a RNA dependent DNA polymerase and they induce syncytia in rat XC cells. The possible significance of these virus particles in radiation osteosarcomagenesis is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of clinical immunology 5 (1985), S. 220-227 
    ISSN: 1573-2592
    Keywords: Program projects and centers ; peer review ; application approval rates ; priority scores ; variability in scores
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the review patterns of applications for program projects and centers in allergy and immunology, reviewed by the National Institute of Allergy and Infectious Diseases review committee, with those of individual research projects in immunology, reviewed by three Division of Research Grants study sections. A high concordance between these review groups was obtained with respect to the application approval rate, mean score, and distribution of applications in various priority score ranges. Furthermore, we observed a high degree of consensus among reviewers on the quality of many program project and center applications, especially those with priority scores between 100 and 200.
    Type of Medium: Electronic Resource
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