ISSN:
1432-1335
Keywords:
α-Difluoromethylornithine
;
Radiation therapy
;
Polyamines
;
Rat glioma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of α-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greater effect on the survival rate than the single therapies, the effect being additive. The concentration of putrescine, spermidine, andN 1-acetylspermidine in tumor tissues was lowered by DFMO, while that of spermine was slightly elevated. Radiation decreased the concentration of all the polyamines, putrescine, spermidine, spermine andN 1-acetylspermidine. The concomitant treatment with DFMO and radiation further decreased the concentrations of putrescine andN 1-acetylspermidine in tumor tissues. The survival period of glioma-bearing rats is inversely correlated with the tissue levels of putrescine plusN 1-acetylspermidine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01410129
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