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  • 1
    Electronic Resource
    Electronic Resource
    The renin-angiotensin-aldosterone system in infancy and childhood in basal conditions and after stimulation (1984)
    Springer
    European journal of pediatrics 143 (1984), S. 18-24 
    Details
    ISSN: 1432-1076
    Keywords: Renin ; Aldosterone ; Sodium restriction ; Posture ; Maturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma renin activity (PRA), aldosterone (PA), sodium and potassium concentration were measured in 107 healthy infants and children under basal conditions of normal diet and recumbency. Urinary aldosterone (UAldo), sodium and potassium were also measured (n=51). A significant (P〈0.001) age-related decrease in PRA (r=-0.67), PA (r=-0.67), and UAldo (r=-0.56) was observed, with a striking scatter of values especially in infancy. The renin-angiotensin-aldosterone system (RAAS) was also studied after stimulation by standardised sodium restriction during 4 days, followed by acute postural change (n=40). After salt restriction a rise of PRA and UAldo was noted, but a rise in PA could not be demonstrated in children aged 0–6 months. The influence of postural change on the RAAS seems more important in older children. The reported values not only in basal but also in stimulated conditions allow study of the RAAS in diseases such as salt loss and hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442742
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Levels of renin, angiotensin I and II, angiotensin-converting enzyme and aldosterone in infancy and childhood (1983)
    Springer
    European journal of pediatrics 141 (1983), S. 3-7 
    Details
    ISSN: 1432-1076
    Keywords: Renin ; Angiotensin ; Angiotensin-converting enzyme ; Aldosterone ; Maturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Basal plasma renin activity (PRA), angiotensin I and II (AI, AII), angiotensin-converting enzyme (ACE) activity and plasma aldosterone (PA) and sodium and potassium concentration were simultaneously measured in 55 healthy recumbent children aged between 1 week and 13 years. A significant (P〈0.001) age-related decrease for PRA (r=-0.73), AI (r=-0.72), AII (r=-0.51) and PA (r=-0.71) was observed but not for ACE (r=0.26, P=0.06). After correction for age the correlation between PRA or PA and AI or AII was still significant (P〈0.005). The strong correlation between AI and AII in the group as a whole (r=0.82, P〈0.001) and also in separate age groups, and an AI to AII ratio which was not different between the various age groups suggest that ACE activity in this age range is not rate-limiting for AII generation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445660
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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