ISSN:
1573-6822
Keywords:
Respiratory epithelium culture
;
cytotoxicity
;
cilio-inhibition
;
epithelial integrity
;
acrolein
;
mechlorethamin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Rabbit trachea primary cultures have been developed as a model to evaluate the toxicity of noxious airborne pollutants. A mucociliary epithelium has been restored in vitro on collagen gel. Several general cytotoxicity assays (viability and growth inhibition) permit a first assessment for the acute toxicity of the tested molecules. More specific criteria such as measurement of the integrity of the epithelial barrier and inhibition of ciliary beat frequency allow to determine a specific impact of xenobiotics on the mucociliary epithelium in culture.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00130521
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