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  • 1
    Electronic Resource
    Electronic Resource
    Use of ceruloplasmin levels to monitor response to therapy and predict recurrence of breast cancer (1983)
    Springer
    Breast cancer research and treatment 3 (1983), S. 221-224 
    Details
    ISSN: 1573-7217
    Keywords: Adjuvant therapy ; breast cancer ; ceruloplasmin ; recurrence prediction ; response to therapy ; tumor markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ceruloplasmin (CP), an acute phase reactant, has been found to be elevated in patients with various tumors including breast cancer. We found that the CP level was elevated in 89% of 103 patients with metastatic breast cancer. In 27 patients with measurable metastatic disease that responded to treatment the mean CP level fell by 35% (p〈0.001) and in 22 patients whose disease progressed on treatment, the mean CP level rose by 44% (p〈0.001). Of those patients with Stage II breast cancer that were treated with adjuvant chemotherapy, only 6% of patients with a normal post mastectomy CP level have recurred, whereas 44% of patients with an elevated post mastectomy CP level have recurred (p〈0.01). In following patients with breast cancer, we noted that in those patients that recurred, the CP level became elevated 16–34 weeks prior to any clinical evidence of metastases. We also noted that the CP level became elevated after initially falling in patients receiving adjuvant chemotherapy and on occasion, the initially elevated CP level did not even fall. These circumstances may represent resistant microscopic disease, so that changing to a noncross-resistant chemotherapeutic regimen might be appropriate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01803564
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum cholesterol reduction with tamoxifen (1990)
    Springer
    Breast cancer research and treatment 17 (1990), S. 3-7 
    Details
    ISSN: 1573-7217
    Keywords: cholesterol ; tamoxifen ; adjuvant therapy ; breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The serum cholesterol levels of 123 consecutively and newly diagnosed women with Stage I and II breast cancer taking tamoxifen were compared with a control group of 81 consecutively newly diagnosed women with Stage I and II breast cancer who were not taking a hormonal treatment or supplement. Other factors that were evaluated were age, menopausal status, tumor size, weight, height, Quetelet index, and smoking and alcohol intake history. The mean cholesterol change in patients on tamoxifen (34.2 ± 3.6 mg/dl) was significantly greater than controls (1.0 ± 4.1 mg/dl) (P〈0.001). Serum cholesterol fell by more than 10 mg/dl in 72.9% of women on tamoxifen vs. 35.1% of controls and by more than 40 mg/dl in 39.9% of women on tamoxifen vs. 12.6% of controls. Multivariate analysis revealed that tamoxifen administration (P〈0.0001), initial cholesterol level (P = 0.001), and age (P = 0.04) were significant factors in producing a decrease in serum cholesterol. The administration of tamoxifen as adjuvant therapy to women with newly diagnosed breast cancer resulted in a significant fall in serum cholesterol. This effect of tamoxifen on the serum cholesterol may prove to be an additional benefit in the form of reduced cardiovascular risk in these women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01812678
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Subtypes of Psychosocial Adjustment to breast cancer (1994)
    Springer
    Journal of behavioral medicine 17 (1994), S. 127-141 
    Details
    ISSN: 1573-3521
    Keywords: breast cancer ; adjustment ; cluster analysis ; coping ; fighting spirit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract By means of cluster analytic techniques, four subtypes of psychosocial adjustment were identified in a sample of 122 breast cancer patients who completed the Psychosocial Adjustment to Illness Scale. Internal consistency and internal validity of the derived typology were suggested by the finding that two different hierarchical agglomerative clustering methods (average linkage between groups, Ward's) produced similar solutions. Three of the derived subtypes reported normal affect levels but different patterns of relative strengths and dysfunctions, while the fourth subtype appeared to be highly distressed and globally maladjusted. External validation was demonstrated by differentiating the subtypes on variables of negative affect, avoidance coping, and fighting spirit. The clinical and heuristic implications of these findings are discussed. The findings highlight the need for comprehensive assessment of psychosocial functioning of cancer patients. They demonstrate that even non-emotionally distressed patients can have very different profiles of adjustment and may benefit from correspondingly individually tailored psychosocial interventions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01858101
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Taurine, amino acid transmitters, and related molecules in the retina of the Australian lungfish Neoceratodus forsteri: a light-microscopic immunocytochemical and electron-microscopic study (1994)
    Springer
    Cell & tissue research 278 (1994), S. 311-326 
    Details
    ISSN: 1432-0878
    Keywords: Retina ; Taurine ; GABA ; Glycine ; Glutamate ; Immunocytochemistry ; Lungfish, Neoceratodus forsteri (Dipnoi)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The morphology of the retina of the Australian lungfish Neoceratodus forsteri was investigated by means of light- and electron microscopy, whilst immunocytochemical studies were performed to determine the cellular distributions of the major amino acid neurotransmitters and other amino acids. The distributions of glycine and GABA were similar to those previously described for teleost, amphibian and mammalian retinae. Labelling was abundant in amacrine cells, whilst GABA was also present in one layer of horizontal cells and some bipolar cells. Taurine was present in both rods and cones, but, unlike the mammalian or avian retina, was absent from other cellular structures, including glial elements. Unexpectedly, the photoreceptor terminals lacked an apparent content of the excitatory amino acid transmitter glutamate. The glutamate that was present in the rods and cones occupied a crescentic arc corresponding to the location of glycogen-rich paraboloids. Asparagine was also present in rods, albeit in the modified mitochondria that formed the elipsoids of the rod inner segments. Arginine, the precursor for formation of nitric oxide, was present in glial cells, and in the paraboloids of both rods and cones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414175
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Immunocytochemical analysis of the transport of arginine analogues into nitrergic neurons and other cells in the retina and pituitary (1997)
    Springer
    Cell & tissue research 290 (1997), S. 501-514 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Arginine ; Analogues ; Immunocytochemistry ; Nitric oxide ; Pituitary ; Retina ; Transport ; Rat (Wistar) ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Nitric oxide is formed by the action of nitric oxide synthase upon l-arginine. The efficacy of some exogenously applied arginine analogues in inhibiting nitric oxide synthase and thus nitrergic transmission indicates that neurons producing nitric oxide may possess an arginine transport system. To investigate whether arginine analogues are preferentially transported into nitric oxide-utilising cells or into cells making other neurochemicals, we have raised highly specific antisera against a number of arginine analogues including NG-methyl arginine, d-arginine, NGnitro-l-arginine, NG-nitro-l-arginine methyl ester and canavanine. Retinae were incubated in physiological media containing these analogues and rats were given intraperitoneal injections of the analogues to study the pituitary. Immunocytochemistry and NADPH-diaphorase histochemistry revealed that many of these analogues could be transported preferentially, but not exclusively, into nitric oxide-generating cells. However, some nitric oxide-producing cells apparently lacked the ability to take up some arginine analogues. We conclude that nitric oxide-generating cells in the retina and pituitary possess one or more arginine transporters. Other subsets of neurons that use GABA or glutamate as a neurotransmitter may also accumulate arginine analogues, possibly as a substrate for formation of these neurochemicals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050957
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    Paper (German National Licenses)
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