ISSN:
1432-1912
Keywords:
Tremor
;
Rigidity
;
α andγ Motor Activity
;
Tremorine
;
Oxotremorine
;
Antitremor Agents
;
Antiparkinson Agents
;
Tremor
;
Rigor -α undγ-motorische Aktivität
;
Tremorin
;
Oxotremorin
;
Antitremorstoffe
;
Antiparkinsonstoffe
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The action of tremorine and oxotremorine on spinal motor activity was studied in the rat. Both tremorogenio agents increased a reflex activity and spontaneousγ activity. The increase in spontaneousγ activity consisted of rhythmic bursts ofγ discharges. The increase in a reflex activity was accompanied by rigidity, which manifested itself by the appearance of tonic muscle activity. Tremorine and oxotremorine-induced tremor was depressed by the antitremor agents metixene and Kr 339, the antiparkinson drugs atropine and biperiden, and the adrenergicβ receptor blocking agents propranolol and pronethalol. The adrenergicα. receptor blocking agents azapetine, dihydroergotamine, haloperidol, phenoxybenzamine and phentolamine failed to inhibit tremor activity. Chlorpromazine, however, as well as procaine, verapamil and DOPA, diminished the intensity of tremor activity without blocking the generation of tremor bursts. Drugs which depressed tremor activity also antagonized the effect of oxotremorine onα andβ motor activity, whereas the drugs, which only diminished tremor intensity, depressed the increasedα reflex discharge without reducing spontaneousγ activity. Rigidity disappeared whenα reflex discharge was normalized. It is concluded that experimental parkinsonlike rigidity may be interpreted in terms of a disturbed balance between monoaminergic and cholinergic mechanisms in the brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997117
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