ZIB

Hits per page

hit 1 - 1 | 1 hit

Sorting

Electronic Resource

The Formal Total Synthesis of Epothilone A (1999)

Kalesse, Markus ; Quitschalle, Monika ; Claus, Eckhard ; [et al.]

Weinheim : Wiley-Blackwell

Liebigs Annalen 1999 (1999), S. 2817-2823

add to mindlist on the mindlist

Details

ISSN: 1434-193X

Keywords: Epothilone A ; Ring-closing metathesis ; Aldol reactions ; Lactones ; Diastereoselective alkylation ; Chemistry ; General Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The formal total synthesis of epothilone A is described. The key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reaction (RCM) and the diastereoselective alkylation at C8. Aldehyde 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An efficient route to keto acid 5 is described.

Type of Medium: Electronic Resource

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

hit 1 - 1 | 1 hit