ISSN:
1434-193X
Keywords:
Ring-closing metathesis
;
Cyclization cleavage
;
N-Heterocycles
;
Amino acids
;
Solid phase
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A Ru-mediated strategy for the cleavage of organic substrate molecules from a solid support via ring-closing metathesis is described. Application of this protocol to solid phase-bound olefinic amino acid derivatives provides various highly functionalized unsaturated N-heterocycles of different ring-sizes in moderate to excellent yields. This strategy features the addition of a stoichiometric amount of styrene to the metathesis mixture, which is shown to increase the yield of the reaction.Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2046/1998/98268_s.pdf or from the author.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
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