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  • 1
    ISSN: 1432-2013
    Keywords: Ontogenesis ; Autonomic nervous system ; SA-node ; Rabbit ; Cat ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of supramaximal vagus nerve stimulation on heart rate were studied in newborn rabbits, cats and guinea pigs. The analysis of the stimulus-effect curve revealed that the carlier proposed relationship: logI f/I o=H·f (I o is the steady state PP-interval before andI f during stimulation,f is the stimulus frequency, andH the slope of the line) accurately summarizes the relation in rabbits, while with minor deviations it also holds for newborn cats and guinea pigs. Thus, the vagus effect for each nerve and animal is characterized by the slope of the line,H. In rabbits and cats the vagus effect decreased during the first postnatal week to about 1/3 and 1/5 of the initial value at birth. Guinea pigs, however, did not show such a postnatal change of the vagus effect. In comparison with rabbits and cats these animals are born at a relatively late ontogenetic stage. Therefore, we hypothesized that the decrease in vagus effect is related to the stage of development and occurs mainly before birth in this species.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 325 (1971), S. 61-76 
    ISSN: 1432-2013
    Keywords: Neonatal Heart ; Vagal Stimulation ; Sino-Auricular Node ; Heart Interval ; Neonatales Herz ; Vagusreizung ; Sinusknoten ; Herz-Intervall
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of young rabbits, aged 0–5 and 9–23 days, the effect on the heart interval of stimulation of the right and left vagal nerves separately was investigated at frequencies of 1, 2, 4, 8 and 16 stimuli per second. Up to and including 8 stimuli per second, this is well described by log10 (I f /I o )=Hf, orI f =I o L f =I o e hf , whereI o andI f are the heart intervals before and during stimulation respectively at frequencyf, L is a lengthening factor,H=log10 L andh=2.3026 H. Thus each increase in vagal stimulation multiplies the heart interval by a constant factor. the response as defined by H were estimated for both right and left vagal nerves in 15 rabbits, and right or left only in 7 others. The responses varied considerably in individual rabbits and were much larger for almost all in the younger group. The effects of right compared with left stimulation, and of deviations of observed from fitted interval ratios, are studied in detail. Some other mathematical forms given in the literature for the response curves are discussed.
    Type of Medium: Electronic Resource
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