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  • 1
    Electronic Resource
    Electronic Resource
    Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 1108-1114 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-dependent diabetes mellitus; polymerase chain reaction ; diabetic nephropathy ; angiotensinogen ; angiotensin converting enzyme ; gene polymorphism.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n = 242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n = 187); a geographically defined cohort of newly diagnosed diabetic patients (n = 341); and IDDM patients with long duration of disease ( 〉 15 years) and no evidence of overt nephropathy (n = 166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p = 0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p = 0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom. [Diabetologia (1996) 39: 1108–1114]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400661
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 1108-1114 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; polymerase chain reaction ; diabetic nephropathy ; angiotensinogen ; angiotensin converting enzyme ; gene polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400661
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Dielectric and13C NMR studies of sulfur dioxide-hydroquinone clathrates (1990)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 8 (1990), S. 187-197 
    Details
    ISSN: 1573-1111
    Keywords: SO2-Hydroquinone clathrate ; SO2-β-quinol clathrate ; dielectric ; solid state13C NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Dielectric measurements of SO2 quinol clathrates show that the reorientation of encaged SO2 molecules is very rapid and depends greatly on the degree of cage occupancy. For aβ-quinol sample of cage occupancyθ = 0.57, the reorientation rate was ∼ 1 MHz at 6 K, with a reorientational activation energy of 673 J/mol. For a sample identified by13C NMR asα-quinol, and for aβ-quinol sample with most cages filled with Xe, SO2 reorientation rates are even greater, with activation energies of only some tens of J/mol. The low temperature dielectric studies show that some ethanol may be enclathrated inβ-quinol recrystallized from this solvent. The13C NMR spectra confirm the X-ray results that the lattice becomes distorted with increased SO2 content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01131296
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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