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Digitale Medien

Starvation in yeast increases non-adaptive mutation (1999)

Marini, A. ; Matmati, N. ; Morpurgo, G.

Springer

Current genetics 35 (1999), S. 77-81

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Details

ISSN: 1432-0983

Schlagwort(e): Key words Adaptive mutations ; 6-N-hydroxylaminopurine ; Saccharomyces cerevisiae

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract The frequency of reversion in a histidine-requiring mutant of Saccharomyces cerevisiae increases about ten-fold in stationary cells during histidine starvation. Histidine starvation enhances a similar frequency of reversion in a tryptophan-requiring mutant. Starvation, therefore, enhances mutation frequencies in a non-adaptive manner. The base analogue 6-N-hydroxylaminopurine (HAP) added prior to plating on medium with limited histidine strongly increases reversion of the histidine mutant. HAP-induced reversion increases further in stationary starving cells with the same kinetics as that which increases spontaneous reversion. Adding HAP to the stationary starving cells does not produce any effect.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002940050435

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