ISSN:
1432-2072
Keywords:
Key words CP-93
;
129
;
Serotonin
;
5-HT1B receptor
;
Parabrachial nucleus
;
Paraventricular nucleus
;
Feeding
;
Satiety
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pons reduced food consumption by rats. The hypophagia was dose-related (ED50 ≈ 1 nmol) and associated with fewer observations of feeding and more periods of inactivity. Water intake, grooming and exploratory activity were unaffected. CP-93,129 also decreased food intake when injected into the hypothalamic paraventricular nucleus, but this action was 50-fold less potent than administration into the PBN. Autoradiography demonstrated 5-HT1B sites in the PBN; this binding was displaced by CP-93,129. The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050570
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