ISSN:
1573-2592
Keywords:
Schoenlein–Henoch purpura
;
sICAM
;
90K/Mac-2 BP protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In order to clarify the immunologic reaction present in Henoch–Schoenlein purpura (HSP), 20 children (11 boys and 9 girls; median age, 5.8 ± 2.8 years) with HSP and 20 sex- and age-matched healthy children were studied. The 90K/Mac-2 BP serum concentrations were significantly higher in the patients than in the healthy controls (12.5 ± 7.5 vs 4.5 ± 2.7 μg/ml, respectively; P 〈 0.0001). 90K/Mac-2 BP values higher than the cutoff value were observed in 13 of 20 (65%) patient. The soluble intercellular adhesion molecule 1 concentrations were significantly higher in HSP patients than controls (P 〈 0.0001), with mean values of 1631 ± 703 and 85 ± 16 ng/ml, respectively. The 90K/Mac-2 BP serum levels were significantly correlated with soluble intercellular adhesion molecule 1 ( r = 0.90, P 〈 0.0001). Although the underlying causes of these immunological abnormalities are unclear, these observations suggest that the 90K/Mac-2 BP protein may play a role in the immunological reactions involved in the development of HSP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1020562702083
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