ISSN:
1434-9949
Keywords:
Antilymphocyte Antibodies
;
Scleroderma
;
CREST Syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The occurrence of antilymphocyte antibodies (AL-Ab) was investigated in the sera of 28 patients with scleroderma. By indirect immunofluorescence, we found these Ab in 53% of the sera. Inhibition of E rosette formation and lymphocytotoxicity revealed these Ab in 42% and 14% of the sera respectively. Most of the Ab (93%) reacted at 0°C. These AL-Ab can be separated into several groups depending on their inhibitory activity on the lymphocyte membrane. In some cases, the receptor seems similar to that of sheep red blood cells. The study of the clinical features of the patients showed few differences between the groups with and those without Al-Ab. It must be noted that all the patients with the CREST syndrome (6 cases) possessed Al-Ab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02031265
Permalink
