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  • 1
    Electronic Resource
    Electronic Resource
    RU 41 656 does not reverse the scopolamine-induced cognitive deficit in healthy volunteers (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 225-231 
    Details
    ISSN: 1432-1041
    Keywords: RU 41 656 ; Scopolamine ; pharmacodynamics ; psychomotor performance ; memory ; drug interaction ; dementia model ; dopamine (D2) agonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The potential antagonism of a single oral dose of RU 41 656 10 mg on the memory and attention disturbances induced by scopolamine 0.6 mg s.c. have been investigated in a 3 period, placebo controlled, double blind, cross over study in 12 healthy, young volunteers. The effects of the compounds were evaluated by objective tests (Buschke selective reminding test, CFF, simple reaction time, tapping, arithmetical calculation) and subjective measurements (visual analogue scale, side effects questionnaire). Measurements were taken before treatment and 2, 4 and 7 h after RU 41 656. Scopolamine caused anterograde amnesia and sedative effects as which were not counteracted by RU 41 656.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315434
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acute effects of amitriptyline on human performance and interactions with diazepam (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 585-592 
    Details
    ISSN: 1432-1041
    Keywords: amitriptyline ; diazepam ; pharmacodynamics ; body sway ; psychomotor performance ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects on psychomotor performance and attention of amitriptyline 75 mg administered without and with diazepam 10 mg have been investigated in 12 healthy subjects. The effects of the compounds were evaluated by objective tests (measurement of body sway, critical flicker fusion, visual reaction time, tachistoscopy, short term visual memory, tapping test, arithmetical calculation and Clement's code) and subjective measurements (visual analogue scales and side effects questionnaire). Measurements were taken before treatment and after 1, 3, 6, 8 and 24 h. Placebo did not affect either the objective or the subjective measurements. Diazepam caused a reduction in attention and performance after 1 h which had disappeared at 3 h. Amitriptyline caused a marked reduction in attention and performance, reaching a peak 3 hours after drug administration and persisting until 8 h. the deterioration in vigilance induced by amitriptyline was potentiated by concomitant diazepam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637593
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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