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  • 1
    Electronic Resource
    Electronic Resource
    Activity of 3β-hydroxysteroid dehydrogenase Δ4–5 isomerase in the human skin (1982)
    Springer
    Archives of dermatological research 274 (1982), S. 289-294 
    Details
    ISSN: 1432-069X
    Keywords: 3β-HSD ; Human skin ; Sebaceous gland ; Dehydroepiandrosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of 3β-hydroxysteroid dehydrogenase Δ4–5 isomerase (3β-HSD) was assayed in various tissues microdissected from the freeze-dried human skin of 13 subjects. The sebaceous gland possessed the highest activity of 3β-HSD in the skin, while the apocrine sweat gland showed only one fourth of that activity. The vellus hair follicle showed nearly one half of the activity of the sebaceous gland, whereas the terminal hair follicle exhibited much lower activity. The activity of the epidermis and of the dermis were negligible. Incubation of fresh whole skin of the forehead with 7α-3H-DHA and subsequent isolation of various tissues revealed that the metabolites identified in the sebaceous gland were androstanedione and androstenedione, whereas testosterone and/or dihydrotestosterone were not detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403732
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Side gland of Suncus murinus as a new model of sebaceous gland: 5α-reductase, androgen receptor, and nuclear androgen content in male and female animals (1989)
    Springer
    Archives of dermatological research 280 (1989), S. 487-493 
    Details
    ISSN: 1432-069X
    Keywords: Sebaceous gland ; Androgen receptor ; 5α-Reductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The side gland of Suncus murinus is composed of well-developed sebaceous glands in both males and females. We measured the 5α-reductase activity, androgen receptor content, and the intranuclear concentrations of testosterone and dihydrotestosterone in this side gland taking it as a new experimental model of human sebaceous glands. Lineweaver-Burk plot analysis suggested the presence of two classes of 5α-reductase with different Km for testosterone in the homogenate. The enzyme activity was slightly higher in males than in females in the presence of a high concentration of testosterone. The levels of androgen receptors were approximately 40 and 30 fmol/mg protein in the cytosol and nuclei, respectively. The values did not differ significantly between males and females. The intranuclear concentration of dihydrotestosterone in the side gland was higher than that of testosterone in each sex. The intranuclear level of each of these two androgens in the female side gland was comparable to that in the male side gland despite the fact that the serum level of testosterone was much lower in the female. These data clearly indicate that the side gland is a typical target tissue for androgens in the female as well as in the male. Androgens other than testosterone may serve as precursors of dihydrotestosterone in the female side gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427662
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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