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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Medical & biological engineering & computing 19 (1981), S. 707-716 
    ISSN: 1741-0444
    Schlagwort(e): BSP models ; Hepatic removal rate ; Liver maximum capacity ; Relative storage capacity ; Secretory transport maximum ; Wheeler-test
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract The fact that the role of conjugation cannot be neglected in the definition and evaluation of the different maximal transfer rates introduced in the literature (Tm, Lm) is demonstrated. Free and conjugated BSP were measured both in blood and bile during constant infusion of free BSP in man. These data proved very useful to develop a careful model of BSP metabolism able to interpret all major known facts in saturation conditions. The model shows that, in the conditions used for the Wheelter-test, biliary excretion is saturated both for free and conjugated BSP. At higher infusion rates, there is also saturation of the hepatic uptake of conjugated BSP. No other processes are saturated in these conditions. Lastly, free and conjugated BSP are excreted at a maximal rate that is not dependent on their respective amounts in the liver; this suggests the existence of independent transport mechanism in biliary excretion for free and conjugated BSP during the infusion of free BSP.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of optimization theory and applications 16 (1975), S. 519-537 
    ISSN: 1573-2878
    Schlagwort(e): Min-max controls ; optimal controls ; nondifferentiable functionals ; two-point boundary-value problems
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract A control problem for actual processes, modeled by simple dynamic linear systems, is studied. A min-max approach is taken, since the problem is reduced to the control of a model, whose output is affected by an input-dependent signal constrained in norm. Particular attention is given to the features of the penalty functional, since it is desired to synthesize the min-max control by means of a feedback on the states of the model; for example, a quadratic functional does not have this property. AnL 1-type functional is then proposed, which is not differentiable; by means of duality techniques, however, the minimization can be carried out. The min-max is obtained both by iterative algorithms, both as a function of the actual value of the model state: this function is the solution of a set of partial differential equations.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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