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Effects of repeated administration of amphetamine on behavioral vigilance: evidence for “sensitized” attentional impairments (1998)

Deller, Thomas ; Sarter, M.

Springer

Psychopharmacology 137 (1998), S. 410-414

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Details

ISSN: 1432-2072

Schlagwort(e): Key words Amphetamine ; Attention ; Sensitization ; Drug addiction ; Psychosis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The effects of repeated intermittent administration of amphetamine (1, 2, 3 mg/kg, IP) on the performance of rats in a task designed to assess sustained attention were tested. A substantial increase in the number of false alarms (i.e., “claims” for hits in non-signal trials) was observed following subsequent administrations of amphetamine. This effect could not be accounted for by drug-induced side or position biases, switching behavior or stereotypy. The effects of repeated amphetamine may model some of the cognitive processes which mediate the attribution of incentive salience to stimuli associated with repeated psychostimulant administration and the development of psychostimulant-induced psychotic symptoms.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002130050637

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