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  • Sepsis  (1)
  • Splenic autotransplantation  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    The role of the spleen and splenic autotransplants in clearing experimental bacteremia caused by the gram-negative bacteriumEscherichia coli (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 229-238 
    Details
    ISSN: 1433-8580
    Keywords: Spleen ; Experimental bacteremia ; E. coli ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several clinical and laboratory studies have demonstrated the risk of sepsis in connection with encapsulated bacteria. The importance of clearing these organisms by the spleen is now well accepted. In contrast, the present work deals with the clearance of non-encapsulated gram-negative bacteria(Escherichia coli). The animals used for the experiments (a heterogenous population of rabbits) were divided into a control group, a splenectomized group, and an autotransplanted group. The histological examination of the splenic transplants revealed typical splenic tissue including lymphatic follicles with germinal activity 42 days after transplantation. For estimation of the clearance capacity different amounts of bacteria were injected i.v. into the rabbits, and colony-forming bacterial cells in the blood were counted at certain intervals. In the control group no bacteria could be detected in the blood after 7 min. All animals of the splenectomized and autotransplanted groups showed a remarkable decrease in clearance efficiency (no bacteria in the blood after 19 min). No difference in the clearance kinetics could be shown between splenectomized and autotransplanted animals. Measuring the uptake of bacterial cells into different organs elicited low incorporation in the spleen as compared to non-immunocompetent organs, but no difference between normal spleen and splenic replants. However, saturation withE. coli cells reached higher limits in the normal spleen than in autotransplants. The immunologic capacity with respect to IgM-producing lymphocytes was measured by the hemolytic plaque assay. The results showed a severe malfunction of the autotransplants as compared to the normal spleen (only 2% of the activity of the control group). Vaccination againstE. coli increased the clearance efficiency in all three groups. The data presented in this paper point out that several functions of the spleen cannot be carried out by autotransplants. The reasons, therefore, may be limited transplant mass and/or decreased specific functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852049
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    81. Immunologische Kapazität und Durchblutung von Milzautotransplantaten — Experimentelle Ergebnisse am Schwein (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 399-403 
    Details
    ISSN: 1435-2451
    Keywords: Splenic autotransplantation ; Immune reaction ; Perfusion ; Pig ; Autologe Milztransplantation ; Immunreaktion ; Durchblutung ; Schwein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Diese Studie beschreibt quantitativ Immunvorgänge und die Durchblutungsrate von Milzregeneraten nach Autotransplantation von Milzgewebe in das Omentum majus. Das Gewicht und die Perfusion der Transplantate 12 Monate postop. waren deutlich reduziert. Die Anzahl der Antikörper-produzierenden Zellen in den Transplantaten war im Vergleich zur normalen Milz nur gering vermindert, während die Milzregenerate das Serum-IgM-Defizit nach Splenektomie nach 4 Monaten ausglichen. Weiters fanden wir verschiedene Proliferationsraten für B- und T-Lymphocyten in den Transplantaten und der normalen Milz nach Mitogenstimulation.
    Notes: Summary The study deals with the immunological capacity and perfusion rate of splenic grafts in pigs after autologous transplantation into the omentum majus. 12 months after operation the weight and relative blood flow of the regenerated splenic tissue were clearly reduced. The number of antibody forming cells in the grafts was only slightly decreased compared to the normal spleen, whereas the autotransplants could balance a serum-IgM-deficiency, observed due to splenectomy, 4 months after grafting. Furthermore the mitogenic stimulation of T- and B-lymphocytes showed different proliferation rates for the autotransplants compared to the spleen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274398
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    Paper (German National Licenses)
    Fulltext
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