ISSN:
1432-1076
Keywords:
Severe aplastic anaemia
;
Granulocyte-colony stimulating factor
;
Erythropoietin
;
Cyclosporin A
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 6-year-old girl with post-hepatitic severe aplastic anaemia was referred to our hospital. Haematological examination showed a haemoglobin level of 5.2 g/dl, platelet count of 8,000/μl, and white blood cell count of 130/μl with 17% neutrophils. She was treated with recombinant human granulocytecolony stimulating factor (15 μg/kg/day i.v.) and cyclosporin A (6 mg/kg/day p.o.). The absolute neutrophil count gradually increased, but Hb and platelets were not improved. The intravenous administration of recombinant human erythropoietin (100 U/kg three times a week) was started, and the reticulocyte count reached 20000/μl on day 12. The platelets increased to 81000/μl after 16 months of combined administration of recombinant human granulocyte-colony stimulating factor, recombinant human erythropoietin and cyclosporin A. After 20 months of combined administration, the haematological results were: Hb, 13.1 g/dl; platelets 80000/μl: WBC, 9500/μl with 40% neutrophils. After recombinant human granulocyte-colony stimulating factor treatment, the myeloid elements of the bone marrow and the number of granulocyte-macrophage colony forming units increased. Bone marrow erythropoiesis and erythroid colonies also increased after recombinant human erythropoietin administration. The clinical course suggested a beneficial effect of haemopoietic growth factors and cyclosporin A in post-hepatitic aplastic anaemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01956411
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