ISSN:
1432-1416
Keywords:
Stress
;
Gluconeogenesis
;
Hormonal regulation
;
Glucocorticoids
;
Hypoxia
;
Hypoglycemia
;
System modelling
;
Parameter identification
;
Simulation
;
Quantitative diagnostic methods
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Mathematics
Notes:
Abstract In this article a system-theoretic approach to hormonal control of gluconeogenesis as observed in the intact organism under hypoglycemia and hypoxia is attempted. Under such conditions the secretion of the stress hormone corticosterone by the adrenal cortex is effected by neural control centres inducing the synthesis of gluconeogenetic enzymes which catalyze the production of glucose from amino acids originating from body tissues. The time courses of the hormonal, enzymatic and metabolic quantities measured are evaluated in the framework of a model in the form of a system of differential equations, the parameters of which are determined by a numerical search procedure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00275438
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