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Digitale Medien

Prazosin selectively antagonizes neuronal responses mediated by α1-adrenoceptors in brain (1981)

Menkes, David B. ; Baraban, Jay M. ; Aghajanian, George K.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 273-275

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Details

ISSN: 1432-1912

Schlagwort(e): Prazosin ; α1-adrenoceptors ; Norepinephrine ; Single unit ; Antihypertensive

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The ability of systemically and locally administered prazosin to block α1-adrenoceptors was examined in two brain areas in the rat. Using single unit recording of neurons in the lateral geniculate and dorsal raphe nuclei, evidence was obtained for the selective blockade of α1-adrenoceptors by both intravenous and iontophoretic prazosin. Since effective systemic doses of prazosin were within the clinical range, it appears likely that brain α1-adrenoceptors would be blocked during prazosin therapy in humans.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00503830

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