ISSN:
1573-4978
Keywords:
alternative splicing
;
SmN
;
imprinting
;
Prader-Willi syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The SmN protein is closely related to the constitutively expressed RNA splicing protein SmB but is expressed only in brain and heart tissue. Mice which lack expression of SmN die shortly after birth suggesting a critical role for this protein possibly in the regulation of neuronal-specific alternative splicing events. We show here however that the neuronal-specific alternative splicing of the RNAs encoding several different classes of protein proceeds normally in mice lacking SmN expression. The potential role of SmN and the reasons for the lethal effect observed in non-expressing mice are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00999851
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