ISSN:
1432-0738
Keywords:
Soman
;
Rat brain
;
Polysomal organization
;
Protein synthesis
;
Cell-free system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of soman on rat brain ribosomes organization and translational activity of mRNA in cellfree system was studied in rats exposed to 1.3 LD50 soman (120 μg/kg body weight) and in rats repeatedly injected with 0.4 LD50 soman (35 μg/kg). Fifteen minutes after the injection of 1.3 LD50 soman the heavy polyribosomal fraction from rat brain was found to be enriched and translational activity of mRNA was enhanced. In rats administered five injections of 0.4 LD50 soman at 24-h intervals, the low density ribosomes appeared as the predominant fraction whereas the activity of mRNA in all cell-free system was significantly impaired. It is concluded that soman intoxication expresses a stimulatory or inhibitory effect on the processes of protein synthesis in the rat brain, depending on the dose schedule of soman administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00316376
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