ISSN:
1432-1106
Keywords:
Baclofen
;
Polysynaptic reflexes
;
Spasticity
;
Intrathecal injection
;
Rabbit
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5–5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 μ or less, the forelimbs were unaffected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00235831
Permalink