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  • 1
    Digitale Medien
    Digitale Medien
    Spider toxin (JSTX-3) inhibits the memory retrieval of passive avoidance tests (1990)
    Springer
    Journal of neural transmission 80 (1990), S. 79-89 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Spider toxin ; JSTX-3 ; memory retrieval ; passive avoidance ; i.c.v
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of a spider toxin (JSTX-3)—a specific blocker of quisqualate sensitive type of glutamate receptors—on learning and memory was studied in mice using passive avoidance tests (step-through and step-down tests) and the water maze test. JSTX-3 was injected into lateral ventricles of chronically cannulated mice at a dose of 22.2 pmol/brain, which did not produce any apparent behavioral changes. This chemical significantly impaired the retrieval of memory in the step-through test and showed a similar (though not statistically significant) tendency in the step-down test, but it had no effect on acquisition or consolidation of memory in both tests. In the water maze test, this chemical had no effect on escape latencies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01245024
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Spider toxin (JSTX-3) inhibits the convulsions induced by glutamate agonists (1990)
    Springer
    Journal of neural transmission 80 (1990), S. 95-104 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Spider toxin ; JSTX-3 ; convulsion ; intracerebroventricular injection ; quisqualate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of a spider toxin (JSTX-3)—a specific blocker of glutamate receptors—on the behavior of mice was studied using an intracerebroventricular (i.c.v.) injection technique. At higher doses (more than 12 nmol/brain), JSTX-3 increased motor activities and induced characteristic symptoms. JSTX-3 at a dose of 4.7 nmol/brain which per se did not produce any abnormal behavior, specifically antagonized quisqualate-induced convulsions but not NMDA- or kainate-induced confulsions. These results indicate that JSTX-3 is a selective antagonist of the quisqualate receptors in the mammalian central nervous system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01257076
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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