ISSN:
1432-0428
Keywords:
Spiny mouse (Acomys cahirinuis)
;
intravenous glucose tolerance
;
insulin in plasma
;
obesity
;
endocrine pancreas
;
insulin secretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A technique was developed to permit estimation of intravenous glucose tolerance and the concomitant immunoreactive insulin (IRI) response in the Geneva colony of the semi-desert rodentAcomys cahirinus. Following intravenous injection of glucose 1.5 g/kg, youngAcomys (2–3 months, 25–35 g body weight) had a significantly lower glucose tolerance (p〈0.01) and a smaller 30 min integrated plasma IRI response (p〈0.001) than age and weight matched albino mice. With increasing age (8 and 21 months) and body weight (57 to 100 g) of theAcomys, glucose tolerance and plasma IRI response decreased further, and in the 21 month old group there were 2 overtly diabetic animals. There was a significant negative correlation between intravenous glucose tolerance and body weight in olderAcomys. The results suggest that pancreatic B-cell responsiveness to glucose is impaired inAcomys of all ages, and that this is associated with poor glucose tolerance which may be aggravated by obesity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01222002
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