ISSN:
1432-2072
Keywords:
Key words Nicotine
;
Prepulse inhibition
;
Schizophrenia
;
Sensorimotor gating
;
Startle
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Rationale: A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. Objective: To determine whether previously reported male〉female acoustic PPI reflect sex differences in smoking effects on PPI, rather than simple sex differences in the regulation of PPI. A retrospective analyses of 〉600 carefully screened normals tested over the past 12 years was completed. Results: Male〉female acoustic PPI was detected in analyses that included: 1) all subjects; or 2) self-declared non-smokers. Conclusions: Sex differences in PPI cannot be accounted for by smoking history, because they are present across a large sample of non-smoking normal controls.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130051111
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